Obsessive-compulsive Disorder in a Patient with 47,XXX, Triple X Syndrome.
- Author:
Jong Hoon KIM
1
;
Young Ho JIN
;
Kee Yong JANG
Author Information
1. National Bukog Mental Hospital, Bukog, Korea.
- Publication Type:Case Report
- Keywords:
Triple X syndrome;
Obsessive-compulsive disorder;
Obsessive-compulsive spectrum disorder
- MeSH:
Amenorrhea;
Aneuploidy;
Brain;
Buspirone;
Female;
Fluoxetine;
Humans;
Magnetic Resonance Imaging;
Obsessive-Compulsive Disorder*;
Psychopathology;
Sex Chromosomes;
Sexual Development
- From:Journal of Korean Neuropsychiatric Association
1999;38(5):1186-1194
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Triple X syndrome is a relatively rare sex chromosomal anomaly, and its association with psychopathology is not well understood. The authors report one case of obsessive-compulsive disorder(OCD)with karyotype-confirmed triple X syndrome, 47,XXX. She had incomplete sexual development, seconddary amenorrhea and multiple obsessive-compulsive symptoms. Magnetic resonance imaging of the brain revealed left occipital white matter hyperintensity lesion. The patient's multiple obsessive-compulsive symptoms were responded partially with fluoxetine and adjunctive buspirone treatment, however, her overall psychological functions were much improved. With the literature reviews, the authors suggest the possibility that a certain type of sex chromosome aneuploidy might be susceptible to obsessive-compulsive spectrum disorders(OCSDs)or OCD.
