Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome.
- Author:
Yong Ho LEE
1
;
Tak KIM
;
Mee Hye KIM
;
Young Tae KIM
;
Sun Haeng KIM
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Korea University Anam Hospital, Seoul.
- Publication Type:Original Article
- Keywords:
Y chromosome;
microdeletion;
idiopathic azoospermia;
Klinefelter syndrome
- MeSH:
Gene Dosage;
Human;
Klinefelter Syndrome/classification/*genetics;
Male;
Oligospermia/classification/*genetics;
Polymerase Chain Reaction;
*Sequence Deletion;
Sequence Tagged Sites;
Spermatogenesis;
X Chromosome/genetics;
Y Chromosome/*genetics
- From:Experimental & Molecular Medicine
2000;32(4):231-234
- CountryRepublic of Korea
- Language:English
-
Abstract:
The objective of this study was to elucidate the cause of the spermatogenic defect in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome. Genomic DNAs from 9 cases of Korean idiopathic azoospermia and 6 of Korean non-mosaic type of Klinefelter syndrome were used for the detection of Y chromosome microdeletions by polymerase chain reaction using 60 primers. Microdeletions of the Y chromosome were found in 1 of 9 (11.1%) patients with idiopathic azoospermia, whereas none was deleted in non-mosaic type of Klinefelter syndrome. This result suggests that Y chromosome microdeletions could be one of the etiologic factors in idiopathic azoospermia.
