Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation.

Author: Minsang SHIN ¹ ; Hye Suk KANG ; Jae Hyung PARK ; Jae Hoon BAE ; Dae Kyu SONG ; Seung Soon IM
Author Information

1. Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Korea.
Publication Type:Review
Keywords: Insulin-like growth factor binding protein 2; Transcriptional regulation; Metabolic diseases; Liver
MeSH: Biological Availability; Gene Expression; Humans; Insulin-Like Growth Factor Binding Protein 2*; Insulin-Like Growth Factor Binding Proteins; Liver; Metabolic Diseases; Obesity; Promoter Regions, Genetic; Protein Isoforms; Transcription Factors
From:Endocrinology and Metabolism 2017;32(1):11-17
CountryRepublic of Korea
Language:English
Abstract: Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region.