The Role of Macrophage Lipophagy in Reverse Cholesterol Transport.
- Author:
Se Jin JEONG
1
;
Mi Ni LEE
;
Goo Taeg OH
Author Information
- Publication Type:Review
- Keywords: Atherosclerosis; Cholesterol efflux; Lipophagy; Macrophages; Reverse cholesterol transport
- MeSH: Atherosclerosis; Autophagy; Cholesterol*; Foam Cells; Homeostasis; Hydrolysis; Lipid Droplets; Lysosomes; Macrophages*
- From:Endocrinology and Metabolism 2017;32(1):41-46
- CountryRepublic of Korea
- Language:English
- Abstract: Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis.
