A Case of Gastric Adenocarcinoma in a Patient with X-linked Agammaglobulinemia.
- Author:
Chang Soo OK
1
;
Jun Haeng LEE
;
Jung Won NOH
;
Seo Young SOHN
;
Bok Soon CHANG
;
Bon Ho KU
;
Won Jung KOH
;
Chang Ohk SUNG
Author Information
1. Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. stomachlee@skku.edu
- Publication Type:Case Report
- Keywords:
X-linked agammaglobulinemia;
Stomach cancer
- MeSH:
Adenocarcinoma;
Agammaglobulinemia;
B-Lymphocytes;
Early Diagnosis;
Gastritis, Atrophic;
Genetic Diseases, X-Linked;
Hematologic Neoplasms;
Humans;
Male;
Metaplasia;
Plasma Cells;
Stomach;
Stomach Neoplasms
- From:Korean Journal of Gastrointestinal Endoscopy
2010;40(1):27-30
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
X-linked agammaglobulinemia is a common type of primary immunodeficiency disorder that's caused by mutation of the BTK gene. The absence of B lymphocytes and plasma cells causes recurrent infections. Patients with X-linked agammaglobulinemia also have a high risk for developing hematological malignancies and, to a lesser degree, carcinoma. We report here on a 26-years-old male patient who suffered with X-linked agammaglobulinemia that was caused by BTK gene mutation, and he developed a gastric cancer in the antrum. He was noted to have chronic atrophic gastritis and diffuse intestinal metaplasia on the endoscopic examination that was done 7 years previously. We recommend regular esophagogastroduodenoscopic evaluation for a patient with X-linked agammaglobulinemia in order to make an early diagnosis of stomach carcinoma.
