Occupational asthma induced by beat-galactosidase.
- Author:
Mi Kyeong KIM
1
Author Information
- Publication Type:Case Report
- Keywords: Beta-galactosidase; Occupational asthma; Immunoinhibition
- MeSH: Allergens; Anti-Bacterial Agents; Aspergillus oryzae; Asthma, Occupational*; beta-Galactosidase; Bronchial Provocation Tests; Dyspnea; Female; Galactosidases; Hospitals, Pediatric; Humans; Infant; Nasal Obstruction; Oryza; Rhinitis; Skin; Sneezing
- From:Allergy, Asthma & Respiratory Disease 2014;2(1):75-77
- CountryRepublic of Korea
- Language:Korean
- Abstract: Galactosidase is generated from Aspergillus oryzae, which is widely used for antidiarrhea medicine to infants. Antibiotics and digestives were reported as a causative allergen inducing occupational asthma. Galatosidase-induced occupational asthma has not been reported yet. A forty-year-old female has suffered from rhinorrhea, sneezing, and nasal obstruction 1 year after handling galactosidase at obstetric and pediatric hospital, and then dyspnea appeared later. Skin prick test with inhalent allergens, beta-galactosidase, and Aspergillus oryzae showed strong positive reaction to beta-galactosidase only. Immunoinhibition test with beta-galactosidase and A. oryzae revealed inhibition to beta-galactosidase only. Bronchial provocation test with beta-galactosidase showed the dual asthmatic response. With these results, we confirmed that the patient has beta-galactosidase-induced occupational asthma and rhinitis.
