The Interaction Between Allelic Variants of CD86 and CD40LG: A Common Risk Factor of Allergic Asthma and Rheumatoid Arthritis.
10.4168/aair.2014.6.2.137
- Author:
So Hee LEE
1
;
Eun Bong LEE
;
Eun Soon SHIN
;
Jong Eun LEE
;
Sang Heon CHO
;
Kyung Up MIN
;
Heung Woo PARK
Author Information
1. Institute of Allergy and Clinical Immunology, Seoul National University College of Medicine, Seoul, Korea. guinea71@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Asthma;
rheumatoid arthritis;
CD86;
CD40 ligand;
genetic polymorphism
- MeSH:
Arthritis, Rheumatoid*;
Asthma*;
CD40 Ligand;
Clinical Coding;
Genetic Predisposition to Disease;
Genotype;
Immune Tolerance;
Korea;
Logistic Models;
Methods;
Multifactor Dimensionality Reduction;
Polymorphism, Genetic;
Polymorphism, Single Nucleotide;
Risk Factors*;
Seoul
- From:Allergy, Asthma & Immunology Research
2014;6(2):137-141
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Allergic asthma (AA) and rheumatoid arthritis (RA) are immune tolerance-related diseases, and immune tolerance is known to be influenced by costimulatory molecules. In this study, we sought to identify common genetic susceptibility in AA and RA. METHODS: Two hundred cases of AA, 184 cases of RA, and 182 healthy controls were recruited at the Seoul National University Hospital, Seoul, Korea. Eight single nucleotide polymorphisms (SNPs) in five genes coding costimulatory molecules, namely, -318C>T, +49A>G, and 6230G>A in CTLA4, IVS3+17T>C in CD28, -3479T>G and I179V in CD86, -1C>T in CD40, and -3458A>G in CD40LG were scored, and genetic interactions were evaluated by multifactor dimensionality reduction (MDR) analysis. RESULTS: MDR analysis revealed a significant gene-gene interaction between -3479T>G CD86 and -3458A>G CD40LG for AA. Subjects with the T/T genotype of -3479T>G CD86 and the A/A genotype of -3458A>G CD40LG were found to be significantly more likely to develop AA than those with the T/T genotype of -3479T>G CD86 and A/- genotype of -3458A>G CD40LG (adjusted OR, 6.09; 95% CI, 2.89-12.98; logistic regression analysis controlled by age). Similarly those subjects showed a significant risk of developing RA (adjusted OR, 39.35; 95% CI, 15.01-107.00, logistic regression analysis controlled by age). CONCLUSIONS: Our findings suggest that a genetic interaction between CD86 and CD40LG favors the development of both AA and RA.
