Polymorphisms of ATF6B Are Potentially Associated With FEV1 Decline by Aspirin Provocation in Asthmatics.
10.4168/aair.2014.6.2.142
- Author:
Tae Joon PARK
1
;
Jeong Hyun KIM
;
Charisse F PASAJE
;
Byung Lae PARK
;
Joon Seol BAE
;
Soo Taek UH
;
Yong Hoon KIM
;
Mi Kyeong KIM
;
Inseon S CHOI
;
Byoung Whui CHOI
;
Hye Rim SHIN
;
Jong Sook PARK
;
Insong KOH
;
Choon Sik PARK
;
Hyoung Doo SHIN
Author Information
1. Department of Life Science, Sogang University, Seoul, Korea. hdshin@sogang.ac.kr
- Publication Type:Original Article
- Keywords:
ATF6B;
aspirin exacerbated respiratory disease (AERD);
single nucleotide polymorphism (SNP);
haplotype
- MeSH:
Adult;
Aspirin*;
Asthma;
Endoplasmic Reticulum;
Haplotypes;
Humans;
Methods;
NF-kappa B;
Phenotype;
Polymorphism, Single Nucleotide;
Transcription Factors
- From:Allergy, Asthma & Immunology Research
2014;6(2):142-148
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Endoplasmic reticulum (ER) stress has recently been observed to activate NF-kappaB and induce inflammatory responses such as asthma. Activating transcription factor 6beta (ATF6B) is known to regulate ATFalpha-mediated ER stress response. The aim of this study is to investigate the associations of ATF6B genetic variants with aspirin-exacerbated respiratory disease (AERD) and its major phenotype, % decline of FEV1 by aspirin provocation. METHODS: Four common single nucleotide polymorphisms (SNPs) of ATF6B were genotyped and statistically analyzed in 93 AERD patients and 96 aspirin-tolerant asthma (ATA) as controls. RESULTS: Logistic analysis revealed that 2 SNPs (rs2228628 and rs8111, P=0.008; corrected P=0.03) and 1 haplotype (ATF6B-ht4, P=0.005; corrected P=0.02) were significantly associated with % decline of FEV1 by aspirin provocation, whereas ATF6B polymorphisms and haplotypes were not associated with the risk of AERD. CONCLUSIONS: Although further functional and replication studies are needed, our preliminary findings suggest that ATF6B may be related to obstructive phenotypes in response to aspirin exposure in adult asthmatics.
