Enhanced Resolution of Eosinophilic Liver Abscess Associated with Toxocariasis by Albendazole Treatment.
10.4166/kjg.2015.65.4.222
- Author:
Eun Young JANG
1
;
Moon Seok CHOI
;
Geum Youn GWAK
;
Kwang Cheol KOH
;
Seung Woon PAIK
;
Joon Hyeok LEE
;
Yong Han PAIK
;
Byung Chul YOO
Author Information
1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. drsmchoi@gmail.com
- Publication Type:Original Article
- Keywords:
Toxocariasis;
Larva migrans, visceral;
Liver abscess;
Liver diseases, parasitic;
Albendazole
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Albendazole/*therapeutic use;
Animals;
Antiprotozoal Agents/*therapeutic use;
Eosinophils/*immunology;
Female;
Humans;
Immunoglobulin G/blood;
Larva Migrans, Visceral/*drug therapy/parasitology;
Liver/enzymology/metabolism;
Liver Abscess/*etiology;
Magnetic Resonance Imaging;
Male;
Middle Aged;
Proportional Hazards Models;
Retrospective Studies;
Tomography, X-Ray Computed;
Toxocara canis/immunology/isolation & purification
- From:The Korean Journal of Gastroenterology
2015;65(4):222-228
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Visceral larva migrans, caused by Toxocara canis and Toxocara cati, has emerged as a significant cause of eosinophilic liver abscess (ELA). Differentiation of ELA associated with toxocariasis (ELA-T) from metastasis or primary liver malignancy is sometimes difficult. However, the role of albendazole treatment remains uncertain in this condition. The aim of this study was to evaluate whether albendazole can enhance the radiologic resolution of ELA-T. METHODS: We retrospectively reviewed the medical records of the patients diagnosed with ELA-T at our institution between January 2008 and December 2011. ELA-T was diagnosed based on the imaging findings on computed tomography or magnetic resonance imaging and the presence of positive serum IgG antibody for Toxocara canis. Among a total of 163 patients, 32 patients received albendazole (albendazole group) and 131 did not (control group). Baseline characteristics and fate of liver nodules were compared between the two groups. RESULTS: Baseline characteristics (age, sex, number and maximal size of lesions, eosinophil count) were similar between the two groups. Median duration for achieving radiologic resolution in the albendazole group was significantly shorter than in the control group (207 days [range 186-228] vs. 302 days [range 224-380], p=0.023). In Cox regression analysis of the cumulative rates of radiologic resolution, the hazard ratio for albendazole treatment was 1.99 (95% confidence interval, 1.22-3.23). CONCLUSIONS: Radiologic resolution of ELA-T can be accelerated with albendazole treatment. Hence, inconvenience associated with long-term follow-up and unnecessary worries among patients can be eliminated with albendazole treatment.
