Alpha Internexin Expression Related with Molecular Characteristics in Adult Glioblastoma and Oligodendroglioma.
10.3346/jkms.2013.28.4.593
- Author:
Ja Hee SUH
1
;
Chul Kee PARK
;
Sung Hye PARK
Author Information
1. Department of Pathology, Seoul National University Hospital, Seoul, Korea. shparknp@snu.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Glioblastoma;
Oligodendroglioma;
Alpha-internexin, humans;
1p/19q Codeletion;
EGFR protein, Human
- MeSH:
Adult;
Brain Neoplasms/*metabolism/mortality/pathology;
Chromosomes, Human, Pair 1;
Chromosomes, Human, Pair 19;
Female;
Gene Deletion;
Glioblastoma/*metabolism/mortality/pathology;
Humans;
Immunohistochemistry;
In Situ Hybridization, Fluorescence;
Intermediate Filament Proteins/genetics/*metabolism;
Kaplan-Meier Estimate;
Male;
Middle Aged;
Oligodendroglioma/*metabolism/mortality/pathology;
Phenotype;
Predictive Value of Tests;
Prognosis;
Receptor, Epidermal Growth Factor/genetics/metabolism
- From:Journal of Korean Medical Science
2013;28(4):593-601
- CountryRepublic of Korea
- Language:English
-
Abstract:
Alpha-internexin (INA) is a proneuronal gene-encoding neurofilament interacting protein. INA is overexpressed mostly in oligodendroglial phenotype gliomas, is related to 1p/19q codeletion, and is a favorable prognostic marker. We studied INA expression in oligodendrogliomas (ODGs) and glioblastomas (GBMs) to verify its association with several molecular phenotypes, 1p/19q codeletion, and epidermal growth-factor-receptor (EGFR) amplification. A total of 230 low- and high-grade ODG and GBM cases was analyzed for INA expression by immunohistochemical staining; and 1p/19q and EGFR gene status was examined by fluorescence in-situ hybridization. INA was positive in 80.3% of ODGs and in 34.3% of GBMs. 1p/19q codeletion was detected in 77.0% of ODGs and 5.5% of GBMs. INA and 1p/19q codeletion were strongly correlated (P < 0.001). The specificity of INA expression for 1p/19q codeletion was 70.8%, while sensitivity was 100%; positive predictive value was 72.5%, and negative predictive value was 29.2% in all 228 tumors. INA expression was correlated with better progression-free survival (PFS) and overall survival (OS) (P = 0.001). In conclusion, INA expression has high specificity and sensitivity to predict 1p/19q codeletion, and it is well correlated with PFS of both ODGs and GBMs. Therefore, INA expression could be a simple, reliable, and favorable prognostic and surrogate marker for 1p/19q codeletion and long term survival.
