In Vitro Activity of Tigecycline Against Orientia tsutsugamushi.
10.3349/ymj.2016.57.4.1034
- Author:
Sun Myoung LEE
1
;
Hae Yoon KWON
;
Jae Hyoung IM
;
Ji Hyeon BAEK
;
Seung Sik HWANG
;
Jae Seung KANG
;
Moon Hyun CHUNG
;
Jin Soo LEE
Author Information
1. Translation Research Center, Inha University School of Medicine, Incheon, Korea.
- Publication Type:Brief Communication
- Keywords:
Orientia tsutsugamushi;
scrub typhus;
tigecycline;
IC50
- MeSH:
Anti-Bacterial Agents/*pharmacology/therapeutic use;
Drug Resistance, Bacterial/drug effects;
Humans;
Inhibitory Concentration 50;
Minocycline/*analogs & derivatives/pharmacology/therapeutic use;
Orientia tsutsugamushi/*drug effects/physiology;
Scrub Typhus/drug therapy
- From:Yonsei Medical Journal
2016;57(4):1034-1037
- CountryRepublic of Korea
- Language:English
-
Abstract:
Scrub typhus is a zoonosis caused by Orientia tsutsugamushi (O. tsutsugamushi) occurring mainly in autumn in Korea. The need of new antibiotics has arisen with a report on strains resistant to antibiotics and chronic infection. This study aims to identify susceptibility of tigecycline in-vitro as a new therapeutic option for O. tsutsugamushi. Antibacterial activity of tigecycline against the O. tsutsugamushi was compared with doxycycline using flow cytometry assay. The inhibitory concentration 50 (IC50) was 3.59×10(-3) µg/mL in doxycycline-treated group. Whereas in 0.71×10(-3) µg/mL tigecycline-treated group. These findings indicate that tigecycline may be a therapeutic option for the treatment of scrub typhus.
