Apolipoprotein B/A1 Ratio as Risk Factor for Cerebral Ischemic Stroke.
10.12771/emj.2012.35.1.21
- Author:
Chorong HAHM
1
;
Ki Sook HONG
Author Information
1. Department of Laboratory Medicine, Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea. kshong@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Apolipoprotein B/A1 ratio;
Cerebral ischemic stroke;
Odds ratio
- MeSH:
Apolipoproteins;
Apolipoproteins B;
Case-Control Studies;
Cholesterol;
Cholesterol, HDL;
Coronary Artery Disease;
Female;
Humans;
Logistic Models;
Odds Ratio;
Risk Factors;
Stroke
- From:The Ewha Medical Journal
2012;35(1):21-25
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: According to current knowledge, apolipoprotein B/A1 (apoB/A1) ratio is like to be risk factor in coronary artery disease. There is evidence form case-control studies that apoB/A1 ratio may be a superior to LDL and HDL cholesterol in discriminating coronary artery disease case subject from control subject. However, relationship between apoB/A1 ratio and cerebral ischemic stroke is undefined. The main object of this study is to determine whether the risk of cerebral ischemic stroke is related to levels of apoB/A1. METHODS: The study group included 643 patients (Men, 372; Women, 271) who diagnosed cerebral ischemic stroke between January 2008 to December 2010. The control groups were composed of 378 patients (Men, 139; Women, 239) who diagnosed other neurological disease. The correlation between lipid profiles and odds ratio of 10 preliminary risk factors (total cholesterol, triglyceride, LDL, HDL, apoA1, apoB, apoB/A1 ratio, non HDL, total cholesterol/HDL ratio, LDL/HDL ratio) for stroke were analyzed. RESULTS: ApoB/A1 ratio was significantly increased in case patients compared with control subjects. Multivariate logistic regression analysis identified decrease of apoB/A1 ratio (odds ratio [OR], 1.583; 95% confidence intercal [CI], 1.105~2.269) as significantly associated with stroke. Individual apoA1 (OR, 1.303; 95% CI, 0.967~1.755) and apoB (OR, 1.397; 95% CI, 0.773~2.523) were also not significantly associated with cerebral ischemic stroke. CONCLUSION: Increase of apoB/A1 ratio is associated with an increase risk of cerebral ischemic stroke. Use of apoB/A1 ratio is efficient as conventional lipids, for the identification of subjects at increased risk of stroke. So apoB/A1 ratio to standard lipid profile testing could improve the evaluation of risk factors of cerebral ischemic stroke.
