Inhibition of Experimental Systemic Inflammation (Septic Inflammation) and Chronic Bronchitis by New Phytoformula BL Containing Broussonetia papyrifera and Lonicera japonica.
- Author:
Hyun Jeong KO
1
;
Oh Song KWON
;
Jeong Ho JIN
;
Kun Ho SON
;
Hyun Pyo KIM
Author Information
1. College of Pharmacy, Kangwon National University, Chuncheon 200-701, Republic of Korea. hpkim@kangwon.ac.kr
- Publication Type:Original Article
- Keywords:
Broussonetia papyrifera;
Lonicera japonica;
Septic inflammation;
Bronchitis
- MeSH:
Animals;
Asian Continental Ancestry Group;
Biomarkers;
Bronchitis;
Bronchitis, Chronic*;
Bronchoalveolar Lavage Fluid;
Broussonetia*;
Cytokines;
Dexamethasone;
Humans;
Inflammation*;
Lonicera*;
Lung Injury;
Mice;
Models, Animal;
Rats;
Tumor Necrosis Factor-alpha
- From:Biomolecules & Therapeutics
2013;21(1):66-71
- CountryRepublic of Korea
- Language:English
-
Abstract:
Broussonetia papyrifera and Lonicera japonica have long been used in the treatment of inflammatory disorders in Chinese medicine, especially respiratory inflammation. Previously, a new phytoformula (BL) containing B. papyrifera and L. japonica was found to exert strong anti-inflammatory activity against several animal models of inflammation, especially against an animal model of acute bronchitis. In the present investigation, the effects of BL on animal models of septic inflammation and chronic bronchitis are examined. Against lipopolysaccharide (LPS)-induced septic inflammation in mice, BL (200-400 mg/kg) reduced the induction of some important proinflammatory cytokines. At 1 h after LPS treatment, BL was found to considerably inhibit TNF-alpha production when measured by cytokine array. At 3 h after LPS treatment, BL inhibited the induction of several proinflammatory cytokines, including IFN-gamma and IL-1beta, although dexamethasone, which was used as a reference, showed a higher inhibitory action on these biomarkers. Against chronic bronchitis induced by LPS/elastase instillation in rats for 4 weeks, BL (200-400 mg/kg/day) significantly inhibited cell recruitment in bronchoalveolar lavage fluid. Furthermore, BL considerably reduced lung injury, as revealed by histological observation. Taken together, these results indicate that BL may have a potential to treat systemic septic inflammation as well as chronic bronchitis.
