The Influence of Varying Dose and Lockout Interval on Patient-controlled Analgesia Using Meperidine.
10.4097/kjae.1998.35.3.531
- Author:
Chang Sung KIM
1
;
Jong Ho CHOI
;
Jae Yong SHIM
;
Keon Hee RYU
;
Yoon Ki LEE
;
Dong Wook KIM
;
Cheol Joo PARK
;
Sung Nyeon KIM
Author Information
1. Department of Anesthesiology, Catholic University Medical College, Seoul, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Analgesia: patient-controlled;
lockout interval;
Analgesics: meperidine;
Pain: postoperative
- MeSH:
Analgesia, Patient-Controlled*;
Anesthesia, General;
Fentanyl;
Humans;
Incidence;
Meperidine*;
Morphine;
Passive Cutaneous Anaphylaxis
- From:Korean Journal of Anesthesiology
1998;35(3):531-537
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The lockout interval is a safe guard to prevent patients from taking additional dose before the full effect of the preceding dose. Therefore, it should correlate with the time-to-peak effect of the opioid selected. The time-to-peak effect of meperidine is known to be different from that of morphine and fentanyl. But there have been few reports about the influence of varying lockout interval on IV-PCA using meperidine. So we studied the influence of varying lockout interval with constant hourly maximum dose on IV-PCA using meperidine. METHODS: This study included sixty patients undergoing low abdominal surgery under general anesthesia. After administration of initial dose of meperidine (0.5 mg/kg) they were randomly assigned to three groups according to the lockout interval; Group 1 (6-min lockout interval, 0.2 mg/kg bolus dose), Group 2 (9-min lockout interval, 0.3 mg/kg bolus dose), Group 3 (12-min lockout interval, 0.4 mg/kg bolus dose). We examined NRS pain score, sedation score, satisfaction score, PCA measurements and the incidence of side effects during 24 hours. RESULTS: There were no significant differences in NRS pain score, sedation score, satisfaction score, the amount of meperidine consumed, injections/attempts ratio and the incidence of side effects among three groups. The numbers of injections and attempts were significantly higher in Group 1 than in Group 2 and Group 3 (P<0.05). CONCLUSIONS: The lockout intervals chosen for this study (6-min, 9-min, 12-min) do not influence pain, side effects, satisfaction and meperidine consumption in IV-PCA using meperidine when hourly maximum dose is constantly 2 mg/kg.
