Polymorphisms of the Serotonin Transporter Gene and G-Protein beta3 Subunit Gene in Korean Children with Irritable Bowel Syndrome and Functional Dyspepsia.
- Author:
Cheong Soo PARK
1
;
Ji Hyun UHM
Author Information
1. Department of Pediatrics, Eulji General Hospital, Eulji University College of Medicine, Seoul, Korea. eomjie@eulji.ac.kr
- Publication Type:Original Article
- Keywords:
Functional dyspepsia;
Irritable bowel syndrome;
Serotonin transporter;
G-protein;
Genotype
- MeSH:
Child;
Dyspepsia;
Genotype;
GTP-Binding Proteins;
Heterotrimeric GTP-Binding Proteins;
Humans;
Irritable Bowel Syndrome;
Rome;
Serotonin;
Serotonin Plasma Membrane Transport Proteins
- From:Gut and Liver
2012;6(2):223-228
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Many candidate gene studies have revealed that polymorphisms of the 5'-flanking controlled SERT gene linked polymorphic region (5HTT-LPR) gene and G-protein beta3 C825T gene might be associated with functional dyspepsia (FD) and irritable bowel syndrome (IBS). This study was performed to investigate polymorphisms of the 5HTT-LPR gene and G-protein beta3 C825T gene in FD and IBS in Korean children. METHODS: In total, 102 patients with FD, 72 patients with IBS based on the Rome III criteria and 148 healthy controls without gastrointestinal symptoms were included in the study to analyze 5HTT-LPR and G-protein beta3 C825T polymorphisms. RESULTS: 5HTT-LPR genotype analysis revealed no signifi cant differences in FD and IBS patients compared with controls. The GNbeta3 C825T genotype distribution for CC, CT, and TT was 23.6%, 53.4%, and 23.0% in controls, 36.3%, 38.2%, and 25.5% in FD and 37.5%, 38.9%, and 23.6% in IBS, respectively. The CC genotype was more common in FD and IBS patients than controls (p<0.05). When the IBS patients were grouped according to IBS subtypes, CC genotype GNbeta3 C825T was common in diarrhea-dominant IBS, and the TT genotype was common in constipation-dominant IBS (p<0.05). CONCLUSIONS: The CC genotype of G-protein beta3 C825T may be associated with FD and diarrhea-predominant IBS. The TT genotype may be associated with constipation-predominant IBS.
