Correlation between Plasma Endothelin-1 Concentrations and Pulmonary Hypertension Associated with Congenital Heart Defects.
- Author:
Sang Ook PARK
1
;
Su Eun PARK
;
Hyang Jae YOO
;
Young Tak LIM
;
Hee Ju PARK
Author Information
1. Department of Pediatrics, College of Medicine, Pusan National University, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Endothelin-l;
Pulmonary hypertension;
Congenital heart defect
- MeSH:
Arterial Pressure;
Busan;
Endothelin-1*;
Heart Defects, Congenital*;
Humans;
Hypertension;
Hypertension, Pulmonary*;
Oxygen;
Pediatrics;
Plasma*;
Pulmonary Artery;
Vascular Resistance
- From:Journal of the Korean Pediatric Society
1996;39(7):970-976
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Endothelin-1 is the most potent vasoconstrictor. This study was investigated the correlation of plasma endothelin-1 and pulmonary hypertension associated with congenital heart defect. METHODS: We evaluated the concentration of ET-1 in 24 cases of congenital heart disease diagnosed at the Department of Pediatrics, Pusan National University, from December 1993 to September 1994. The patients were divided into 2 groups according to mean pulmonary arterial pressure: Pulmonary artery hypertension group(Group I) and normal pulmonary artery pressure group(Group II). Between 2 groups, there was no statistical significance in mean age, sex and oxygen saturation. GroupI included 9 patients of VSD and 1 patient of COA. Group II included 9 patients of VSD, 3 patients of TOF and 1 patient of PS, 1 patient of PS with DORV. RESULTS: The results were summarized as follows; 1) The mean pulmonary arterial pressure and pulmonary-to-systemic flow ratio (Qp/Qs), pulmonary vascular resistance in GroupIwere significantly higher than those in Group II. 2) The plasma concentrations of ET-1 in GroupI was significantly higher than those in Group II. 3) But there were no statistical significance between the concentrations of ET-1 and the mean pulmonary artery pressure, Qp/QS, pulmonary vascular resistnace. CONCLUSIONS: Based on these results, plasma ET-1 concentraions were elevated in patients with pulmonary hypertension associated with congenital heart defects.
