Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells.
10.7180/kmj.2015.30.2.103
- Author:
Sun Yong HWANG
1
;
Tae Hee KIM
;
Hae Hyeog LEE
;
Heung Yeol KIM
;
Juhyun SEO
Author Information
1. Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Asan, Republic of Korea.
- Publication Type:Review
- Keywords:
Apoptosis;
breast neoplasms;
docosahexaenoic acid;
metastasis;
proliferation
- MeSH:
Apoptosis;
Breast Neoplasms*;
Breast*;
Caspase 8;
Caspase 9;
Cell Line;
Lipid Peroxidation;
MCF-7 Cells;
Neoplasm Metastasis;
Reactive Oxygen Species
- From:Kosin Medical Journal
2015;30(2):103-107
- CountryRepublic of Korea
- Language:English
-
Abstract:
Today, many materials as drug are developed having various prominent function in order to treatment of disease or cancer. Among these materials, especially docosahexaenoic acid (DHA), main constituents of omega-3 fatty acid, has a lot of beneficial and natural effects, so it has been known as anticancer material especially breast cancer. Breast cancer is disease taking high occurrence level among feminine diseases. DHA has anticancer effects on breast cancer cell, representatively inducing apoptosis, inhibiting proliferation or metastasis. Main effect of DHA on breast cancer cell is apoptosis inducing, which has mechanism that treated DHA causes lipid peroxidation increasing reactive oxygen species (ROS) level and it activates caspase 8 and caspase 9 so activated caspase occurs apoptosis. Cell lines of breast cancer are MDA-MB-231, MCF-7, SK-BR-3, T47D and ZR75. Especially this article uses the MCF-7 cell line at experiment of anti-proliferation by DHA, the MDA-MB-231 cell line at experiment of anti-metastasis by DHA, because that cell line has specialized metastasis activity. Therefore, this paper discusses the effects of natural material DHA as drug of breast cancer.
