Treatment of Gonorrhoea.
10.5021/ad.1989.1.2.69
- Author:
Joong Hwan KIM
;
Hong Yoon YANG
;
Young Tae KIM
- Publication Type:Original Article
- Keywords:
PPNG;
Spectinomycin;
Treatment of gonorrhoea
- MeSH:
Anti-Bacterial Agents;
Cefoperazone;
Diagnosis;
Drug Therapy;
Humans;
Male;
Penicillinase;
Penicillins;
Prevalence;
Seoul;
Spectinomycin;
Treatment Failure;
Urethritis
- From:Annals of Dermatology
1989;1(2):69-72
- CountryRepublic of Korea
- Language:English
-
Abstract:
Because of increasing resistance of circulating N. gonorrhoeae and frequent failures in the treatment of gonorrhoea, intensive work on gonorrhoea has become of paramount importance. During January 1980-April 1984, at the Choong-Ku VD Clinic in Seoul, 3,340 male patients with uncomplicated gonococcal urethritis were treated with various treatment regimens. Diagnosis of gonorrhoea and declaration of a treatment failure were made on the basis of positive urethral culture. In 1984, the prevalence of Penicillinase Producing N. gonorrhoeae (PPNG) was about 30%, The pretreatment minimun inhibitory concentration of various antibiotics were quite high. Even for non-PPNG urethritis standard penicillin regimens gave unsatisfactory results. For PPNG urethritis, only spectinomycin, cefoperazone and cefotaxim-probenecid regimens gave satisfactory results. No spectmomycin resistant strain of N. gonorrhoeae has been found since 1982 at the Choong-Ku VD Clinic. As an agent of single drug therapy, spectinomycin seems to be one of the most cost effective drugs in the treatment of uncomplicated gonorrhoea in men.
