Epidermolysis Bullosa Acquisita.
10.5021/ad.1989.1.2.73
- Author:
Chang Woo LEE
;
Hong Yoon YANG
;
Moon Hyang PARK
- Publication Type:Case Report
- Keywords:
Early inflammatory form;
Epidermolysis bullosa acquisita
- MeSH:
Adult;
Autoantibodies;
Basement Membrane;
Biopsy;
Blister;
Blotting, Western;
Epidermolysis Bullosa Acquisita*;
Epidermolysis Bullosa*;
Female;
Fluorescent Antibody Technique, Direct;
Humans;
Immunoglobulin G;
Neutrophils;
Prednisolone
- From:Annals of Dermatology
1989;1(2):73-76
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 40-year-old woman had a pruritic, vesiculobullous eruption of her face for 6 weeks with no evidence of systemic disease. A biopsy showed subepidermal blisters and dermal infiltrates of neutrophilic inflammatory cells. Direct immunofluorescence demonstrated thick linear deposits of IgG and C3 along the basement membrane zone. The cleavage plane was identified to be just beneath the lamina densa. Using Western immunoblots, the patient's IgG autoantibodies were found to recognize type VII proeollagen. Moderate starting doses of systemic prednisolone gave a good response for this patient with an early inflammatory form of epidermolysis bullosa acquisita.
