The Effect of Fluoxetine on Behaviors in Transient Forebrain Ischemic Gerbil.
- Author:
Hua LI
1
;
Do Hoon KIM
;
Moo Ho WON
;
Ji Jing YAN
Author Information
1. Department of Psychiatry, College of Medicine, Hallym University, Chunchon Sacred Heart Hospital, Chuncheon, Korea. dohkim@hallym.ac.kr
- Publication Type:Original Article
- Keywords:
Transient forebrain ischemia;
Fluoxetine;
Novel object recognition test;
Spontaneous motor activity;
Learned helplessness test
- From:Korean Journal of Psychopharmacology
2006;17(6):565-572
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This study aims to explore the effect of fluoxetine on memory, locomotor and depressive behavior in transient forebrain ischemic model of gerbil. METHODS: Doses of fluoxetine (10, 40 mg/kg) or vehicle were intraperitoneally administered once 30 min before ischemic surgery in gerbil. Novel object recognition test, spontaneous motor activity, learned helplessness test were performed 4 days, 8 days, or 9 days, respectively, after sham or ischemic surgery. RESULTS: Fluoxetine treatment (40 mg/kg) significantly reduced recognition memory in sham operated gerbil. However, fluoxetine (10, 40 mg/kg) did not affect ischemia-induced impairment in recognition memory. The treatment of fluoxetine (10, 40 mg/kg) significantly inhibited locomotor hyperactivity induced by transient ischemia even though fluoxetine (40 mg/kg) did not affect spontaneous motor activity in the sham operated gerbils. Fluoxetine did not affect depressive behavior in sham and ischemic gerbils. CONCLUSION: The treatment of fluoxetine inhibited ischemia-induced hyperactivity, but did not affect memory and depressive behavior in transient forebrain ischemic gerbils.
