Short-term follow up of thyroid function after pediatric hematopoietic stem cell transplantation.
10.3345/kjp.2006.49.11.1211
- Author:
Seon Ju LEE
1
;
Jae Wook LEE
;
Dae Hyoung LEE
;
Young Joo KWON
;
Young Shil PARK
;
Hui Sung HWANG
;
Sun Young KIM
;
Ji Kyoung PARK
;
Pil Sang JANG
;
Min Ho JUNG
;
Nak Gyun CHUNG
;
Dae Chul JEONG
;
Bin CHO
;
Hack Ki KIM
;
Byung Churl LEE
Author Information
1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. chobinkr@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Thyroid function;
Euthyroid sick syndrome;
Hematopoietic stem cell transplantation
- MeSH:
Child;
Euthyroid Sick Syndromes;
Follow-Up Studies*;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation*;
Hematopoietic Stem Cells*;
Humans;
Incidence;
Multivariate Analysis;
Risk Factors;
Thyroid Gland*;
Thyrotropin;
Thyroxine;
Triiodothyronine
- From:Korean Journal of Pediatrics
2006;49(11):1211-1215
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In this study, we analyzed the short term changes of thyroid function, incidence and risk factors of thyroid dysfunction soon after allogeneic hematopoietic stem cell transplantation (HSCT) in children. METHODS: We enrolled 80 pediatric patients following allogeneic HSCT, at the Catholic HSCT center between January, 2004 and February, 2006. Serum TSH (thyroid stimulating hormone), total serum thyroxine and total serum triiodothyronine levels were systematically measured in 80 patients before the HSCT, and at 1 month, 6 months and 12 months after HSCT. RESULTS: Thyroid function statistically decreased at 1 month after HSCT(P < 0.001). Thyroid dysfunction at 1 month was observed in 43 (54 percent) of 80 patients, 31 (39 percent) of whom presented with euthyroid sick syndrome (ETS). Thyroid dysfunction was normalized within 1 year after HSCT. In univariate analysis, malignant disease and the presence of acute graft-versus-host disease (grade > or = II) were risk factors for ETS (P=0.04, 0.01 respectively). In multivariate analysis, we could not detect an independent risk factor for ETS (P=0.19, 0.06 respectively). CONCLUSION: The present study suggests that the incidence of thyroid dysfunction is high after allogeneic HSCT. Therefore, regular monitoring of thyroid hormone levels after HSCT is required.
