Efficacy and Tolerability of Solifenacin 5 mg Fixed Dose in Korean Children with Newly Diagnosed Idiopathic Overactive Bladder: a Multicenter Prospective Study.
10.3346/jkms.2017.32.2.329
- Author:
Sang Don LEE
1
;
Jae Min CHUNG
;
Dong Il KANG
;
Dong Soo RYU
;
Won Yeol CHO
;
Sungchan PARK
Author Information
1. Department of Urology, Pusan National University Yangsan Hospital and Research Institute for Convergence of Biomedical Science and Technology, Yangsan, Korea.
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Anticholinergics;
Child;
Efficacy;
Overactive Bladder;
Tolerability
- MeSH:
Child*;
Cholinergic Antagonists;
Humans;
Prospective Studies*;
Solifenacin Succinate*;
Urinary Bladder;
Urinary Bladder, Overactive*;
Urinary Incontinence
- From:Journal of Korean Medical Science
2017;32(2):329-334
- CountryRepublic of Korea
- Language:English
-
Abstract:
We investigated the efficacy and tolerability of solifenacin 5 mg fixed dose in children with newly diagnosed idiopathic overactive bladder (OAB). A total of 34 children (male/female patients = 16/18) aged under 13 years (mean age: 7.2 ± 2.3; range: 5–12) who were newly diagnosed with OAB from January 2012 to September 2014 were prospectively evaluated with open-label protocol. All patients were treated with solifenacin 5 mg fixed dose once daily for at least 4 weeks. The efficacy and tolerability of solifenacin were evaluated 4, 8, and 12 weeks after the initiation of treatment. The mean voiding frequency during daytime was decreased from 9.4 ± 3.0 to 6.5 ± 2.3 times after the 12-week treatment (P < 0.001). The mean total OAB symptom score (OABSS) decreased from 7.7 ± 4.2 to 3.1 ± 3.1 after the 12-week treatment (P < 0.001). The urgency and urgency urinary incontinence (UUI) domains significantly improved from the 12-week treatment, and complete resolution of urgency occurred in 38.9% of patients and the percentage of children with UUI among urgent patients decreased from 79.4% to 57.1%. According to 3-day voiding diaries, the average bladder capacity increased from 90.4 ± 44.4 to 156.2 ± 67.3 mL (P < 0.001). Drug-induced adverse effects (AEs) were reported in 7 patients (20.6%). Our results indicate that solifenacin 5 mg fixed dose is effective against OAB symptoms, and its tolerability is acceptable without significant AEs in children with OAB.
