Prostate Cancer in a Patient with a Family History of BRCA Mutation: a Case Report and Literature Review.
10.3346/jkms.2017.32.2.377
- Author:
Won Hoon SONG
1
;
Sung Han KIM
;
Jae Young JOUNG
;
Weon Seo PARK
;
Ho Kyung SEO
;
Jinsoo CHUNG
;
Kang Hyun LEE
Author Information
1. Department of Urology, Seoul National University Hospital, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Prostate Cancer;
BRCA;
Genetic Mutation;
Family History
- MeSH:
Breast;
Breast Neoplasms;
Colorectal Neoplasms;
Gait;
Germ-Line Mutation;
Humans;
Mass Screening;
Middle Aged;
Neoplasm Metastasis;
Phenotype;
Prognosis;
Prostate*;
Prostatic Neoplasms*;
Risk Factors;
Stomach
- From:Journal of Korean Medical Science
2017;32(2):377-381
- CountryRepublic of Korea
- Language:English
-
Abstract:
One of the most significant risk factors for prostate cancer (PC) is a family history of the disease, with germ-line mutations in the breast cancer predisposition gene (BRCA) 2 conferring the highest risk. We here report a 56-year-old man presented with painful gait disturbance and diagnosed PC with multiple disseminated bone metastases. The patient had a strong family history of breast cancer with his 2 nieces affected. Furthermore, his aunts and uncles from both sides were diagnosed with stomach, ovarian, and colorectal cancers. His genomic sequencing analysis of the BRCA genes revealed the same BRCA2 deleterious mutation that his breast cancer-affected nieces carried. Previous studies have suggested that BRCA2-mutated PC is associated with a more aggressive phenotype and poor prognosis. Our experience in the present case also indicated the urgent needs for novel treatment modality and PC screening in this high-risk group of patients.
