Clinical significance of specific IgG and IgE antibodies to toluene diisocyanate ( TDi ) - human - serum albumin ( HSA ) conjugate in TDI - induceed occupational asthma.
- Author:
Hae Sim PARK
;
Hee Yeon KIM
;
Jung Hee SUH
;
Dong Ho NAHM
;
Jee Woong SOHN
;
You Young KIM
- Publication Type:Original Article
- Keywords:
TDI - induced occupational asthma;
specific IgG;
specific IgE;
TDI - bronchoprovocation test
- MeSH:
Antibodies*;
Asthma;
Asthma, Occupational*;
Enzyme-Linked Immunosorbent Assay;
Humans*;
Immunoglobulin E*;
Immunoglobulin G*;
Korea;
Prevalence;
Serum Albumin*;
Toluene 2,4-Diisocyanate*;
Toluene*
- From:Journal of Asthma, Allergy and Clinical Immunology
1999;19(4):594-600
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVE: TDI is known to be the most prevalent cause of occupational asthma ( OA ) in Korea. However, the pathogenesis of TDI - induced occupational asthma still remains to be further clarified. So, we evaluated clinical significance of serum specific IgG and IgE antibodies to TDI - HSA conjugate in TDI - induced occupational asthma. Subjects and METHODS: Serum specific IgG and IgE antibodies to TDI - HSA conjugate were measured by enzyme linked immunosorbent assay. Serum was collected from 50 TDI- induced OA patients ( classified as group I ), and was compared with that from 13 asthmatic subjects with negative TDI - bronchoprovocation test ( BPT, group II ), allergic asthmatics ( group III ), and unexposed healthy controls ( group IV ). RESULTS: The prevalence of specific IgG was significantly higher in group I than in group II (p = 0.01) or group III (p <0.01). No significant difference was noted between group II and group III (p> 0.05). However, the prevalence of specific IgE was not different between group I and group II (p> 0.05 ) or group II and group III( p> 0.05 ). There was no significant difference in prevalence of specific IgG according to the asthmatic response during TDI bronchoprovocation test ( p> 0.05 ). No statistical significance was noted between specific IgG and IgE antibodies in group I subjects ( p> 0.05 ). CONCLUSION: These findings demonstrate that presence of specific IgG to TDI - HSA conjugate is closely related to TDI - BPT results and it may contribute to the development of TDI - induced asthma.
