Pituitary Epithelioid Osteosarcoma after Gamma-knife Surgery of a Pituitary Adenoma.
10.3904/kjm.2017.92.2.195
- Author:
So Young PARK
1
;
You Jin KIM
;
Eun Jeong LEE
;
Jae Shin CHOI
;
Jae Hyeon KIM
;
Sang Man JIN
;
Kyu Yeon HUR
Author Information
1. Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ky.hur@samsung.com
- Publication Type:Case Report
- Keywords:
Gamma knife radiosurgery;
Pituitary;
Sarcoma
- MeSH:
Diagnosis;
Female;
Humans;
Middle Aged;
Osteosarcoma*;
Pituitary Neoplasms*;
Pterygopalatine Fossa;
Radiosurgery;
Radiotherapy;
Sarcoma
- From:Korean Journal of Medicine
2017;92(2):195-199
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
With the increasing use of stereotactic radiosurgery, recent reports have suggested that stereotactic radiosurgery may induce secondary malignancies. While the risk of secondary malignancy after conventional radiotherapy is well known, its development after stereotactic radiosurgery has been reported in only a few cases. Here we present the case of a 56-year-old female with visual disturbance of sudden onset. She underwent trans-sphenoidal surgery for a pituitary adenoma 13 years earlier. Imaging studies revealed a newly developed pituitary mass invading the right carvenous sinus. Gross total resection of the tumor was performed using a trans-sphenoidal and pterygopalatine fossa approach. The histological diagnosis was pituitary epithelioid osteosarcoma. Clinicians should be aware of the rare occurrence of radiation-induced pituitary sarcoma as a potentially fatal late complication of stereotactic radiosurgery.
