Association between Recent Acetaminophen Use and Asthma: Modification by Polymorphism at TLR4.
10.3346/jkms.2014.29.5.662
- Author:
Seung Hwa LEE
1
;
Mi Jin KANG
;
Ho Sung YU
;
Kyungmo HONG
;
Young Ho JUNG
;
Hyung Young KIM
;
Ju Hee SEO
;
Ji Won KWON
;
Byoung Ju KIM
;
Ha Jung KIM
;
Young Joon KIM
;
Hee Suk KIM
;
Hyo Bin KIM
;
Kang Seo PARK
;
So Yeon LEE
;
Soo Jong HONG
Author Information
1. Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Acetaminophen;
Asthma;
Bronchial Hyperresponsiveness;
Toll-Like Receptor 4;
Gene-Environment Interaction
- MeSH:
Acetaminophen/*adverse effects/therapeutic use;
Adolescent;
Asthma/chemically induced/epidemiology/*genetics;
Bronchial Hyperreactivity/chemically induced/epidemiology/*genetics;
Child;
Cross-Sectional Studies;
Eosinophils/immunology;
Female;
Genetic Predisposition to Disease;
Genotype;
Humans;
Immunoglobulin E/blood/immunology;
Inflammation/immunology;
Male;
Oxidative Stress/drug effects;
Polymorphism, Single Nucleotide;
Questionnaires;
Reactive Oxygen Species/immunology;
Risk;
Risk Factors;
Toll-Like Receptor 4/*genetics
- From:Journal of Korean Medical Science
2014;29(5):662-668
- CountryRepublic of Korea
- Language:English
-
Abstract:
The risk of asthma has been increasing in parallel with use of acetaminophen, which is a potential source of oxidative stress. Toll-like receptor 4 (TLR4) plays a critical role not only in innate immunity, but also in mediating reactive oxygen species induced inflammation. Therefore, we investigated associations between acetaminophen usage and TLR4 polymorphism on asthma and bronchial hyperresponsiveness (BHR). The number of 2,428 elementary school children in Seoul and Jeongeup cities was recruited. Subjects who used acetaminophen with a family history of asthma had an increased risk of both asthma diagnosis ever and current asthma. Individuals with CT+TT genotypes at the TLR4 polymorphism, in combination with acetaminophen usage, also demonstrated an increased risk of asthma diagnosis ever (aOR, 2.08; 95% confidence interval [CI], 1.10-3.92). Family history of asthma and acetaminophen usage were risk factors for BHR. Although TLR4 was not an independent risk factor for BHR, individuals with CT+TT genotypes at the TLR4 polymorphism had an increased risk of BHR when combined with acetaminophen usage (aOR, 1.74; 95% CI, 1.03-2.94). In conclusion, acetaminophen usage may be associated with asthma and BHR in genetically susceptible subjects. This effect may be modified by polymorphism at TLR4.
