Role of 5-HT1A Receptors in Learning and Memory.
- Author:
Ji Woong KIM
1
Author Information
1. Department of Psychiatry, College of Medicine, Konyang University, Daejeon, Korea. cortex@konyang.ac.kr
- Publication Type:Review
- Keywords:
5-HT1A receptor;
Learning;
Memory
- MeSH:
Korea;
Learning*;
Memory*;
Receptor, Serotonin, 5-HT1A*;
Serotonin;
Synaptic Transmission
- From:Korean Journal of Psychopharmacology
2007;18(5):271-279
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Growing evidence indicates that the serotonin system is important in learning and memory. In particular, several preclinical and clinical studies suggest that modulating the 5-HT1A receptor can influence learning and memory, and indeed, it has been observed that presynaptic 5-HT1A receptor agonists and postsynaptic 5-HT1A receptor antagonists tend to ameliorate the learning/memory impairment induced by various methods. In contrast, post-synaptic 5-HT1A receptor agonists tend to decrease the learning/memory function. These observations suggest the possibility that modulating neurotransmission mediated by the 5-HT1A receptor may be effective as a therapeutic strategy for enhancing learning and memory in various neuropsychiatric disorders. Unfortunately, there is no available discussion on the relationship between 5-HT1A receptor and learning/memory in Korea. This article reviews the clinical or preclinical literature on this issue.
