Predictive Factors for Long-term Clinical Outcomes in Patients with Variant Angina.
- Author:
Myung Ja CHOI
1
;
Myung Ho JEONG
;
Jae Yeong CHO
;
Young Sook LEE
;
Jung Ae RHEE
;
Jin Su CHOI
;
Doo Sun SIM
;
Keun Ho PARK
;
Young Joon HONG
;
Ju Han KIM
;
Young Keun AHN
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Jung Chaee KANG
Author Information
1. The Heart Center of Chonnam National University Hospital, Gwangju, Korea. myungho@chollian.net
- Publication Type:Original Article
- Keywords:
Smoking;
Coronary artery disease;
Angina pectoris, Variant
- MeSH:
Angina Pectoris, Variant;
Angiography;
Cardiac Catheterization;
Cardiac Catheters;
Cholesterol;
Coronary Artery Disease;
Death;
Ergonovine;
Follow-Up Studies;
Humans;
Incidence;
Ischemia;
Korea;
Lipoproteins;
Myocardial Infarction;
Risk Factors;
Smoke;
Smoking
- From:Korean Journal of Medicine
2013;84(4):522-530
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The incidence of variant angina (VA) is relatively high in Korea compared with western countries, but its long-term clinical outcomes are not well defined. METHODS: Patients who underwent ergonovine provocation tests at the cardiac catheterization laboratory of Chonnam National University Hospital between 1996 and 2011 were enrolled in this study (n = 1162). Of them, 686 patients with positive ergonovine provocation tests were divided into two groups: patients with cardiac events (Group I: 153 patients, 52.4 +/- 11.0 years, M: F = 103: 50) and those without (Group II: 533 patients, 51.6 +/- 10.7 years, M: F = 350: 183). The mean follow-up duration was 40.2 +/- 38.0 months. Cardiac events were defined as cardiac death, recurrent ischemia, rehospitalization, myocardial infarction, and follow-up angiography. Clinical findings, laboratory and coronary angiographic characteristics were compared between the groups. RESULTS: A history of smoking was more common in Group I than in Group II (45.8% vs. 36.3%, p = 0.037). The levels of low-density lipoprotein cholesterol (119.4 +/- 35.3 vs. 111.1 +/- 32.2 mg/dL, p = 0.010) were higher in Group I than in Group II. According to Cox proportional hazard regression analysis, the major predictive factor for cardiac events during clinical follow-up was smoking (HR 1.80, 95% CI 1.036-3.126, p = 0.037). CONCLUSIONS: A history of smoking was the only independent risk factor for cardiac events during a long-term clinical follow-up in Korean patients with variant angina.
