Mesenteric Fibromatosis Presenting as a Submucosal Tumor of the Jejunum.
- Author:
Changyoung YOO
1
;
Chan Kwon JUNG
;
Kyo Young SONG
;
Eun Sun JUNG
;
Kyo Young LEE
Author Information
1. Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea. ckjung@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Mesenteric fibromatosis;
beta-catenin;
Immunohistochemistry;
Small intestine
- MeSH:
Adenomatous Polyposis Coli;
Adult;
beta Catenin;
Collagen;
Diagnosis, Differential;
Female;
Fibroblasts;
Fibroma;
Gastrointestinal Tract;
Humans;
Immunohistochemistry;
Intestine, Small;
Jejunum
- From:Journal of the Korean Surgical Society
2008;74(4):312-315
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mesenteric fibromatoses occur as sporadic lesions or as parts of familial adenomatous polyposis, are clonal lesions prone to locally aggressive behavior, but lack metastatic capacity. Fibromatoses harbor somatic beta-catenin or adenomatous polyposis coli (APC) mutations, leading to intranuclear accumulation of b-catenin. We report a case of mesenteric fibromatosis presenting as a 5.4x4.8 cm submucosal tumor of the jejunum in a 42-year-old woman. Histologically, the tumor consisted of proliferation of bland, elongated-spindle fibroblasts with collagen deposition and a characteristic prominent vasculature. Immunohistochemically, the tumor cells showed nuclear staining for beta-catenin. Mesenteric fibromatosis should be included in the differential diagnosis of submucosal spindle cell tumors of the gastrointestinal tract, and nuclear immunoreactivity for beta-catenin may help distinguish these tumors form histological mimics.
