Validation of Self-administrated Questionnaire for Psychiatric Disorders in Patients with Functional Dyspepsia.
- Author:
Ada W Y TSE
1
;
Larry H LAI
;
C C LEE
;
Kelvin K F TSOI
;
Vincent W S WONG
;
Yawen CHAN
;
Joseph J Y SUNG
;
Francis K L CHAN
;
Justin C Y WU
Author Information
1. Kwai Chung Hospital, Hospital Authority, Hong Kong S.A.R., China.
- Publication Type:Original Article
- Keywords:
Dyspepsia;
Questionnaires;
Psychiatric diagnosis;
Quality of life
- MeSH:
Area Under Curve;
Axis, Cervical Vertebra;
Comorbidity;
Diagnostic and Statistical Manual of Mental Disorders;
Dyspepsia;
Early Intervention (Education);
Gastroenterology;
Gastroesophageal Reflux;
Health Surveys;
Humans;
Linear Models;
Mass Screening;
Mental Disorders;
Psychiatry;
Quality of Life;
Surveys and Questionnaires;
Risk Factors;
ROC Curve;
Rome;
Sensitivity and Specificity
- From:Journal of Neurogastroenterology and Motility
2010;16(1):52-60
- CountryRepublic of Korea
- Language:English
-
Abstract:
INTRODUCTION: Psychiatric comorbidity is common in patients with functional dyspepsia (FD) but a good screening tool for psychiatric disorders in gastrointestinal clinical practice is lacking. Aims: 1) Evaluate the performance and optimal cut-off of 12-item General Health Questionnaire (GHQ-12) as a screening tool for psychiatric disorders in FD patients; 2) Compare health-related quality of life (HRQoL) in FD patients with and without psychiatric comorbidities. METHODS: Consecutive patients fulfilling Rome III criteria for FD without medical co-morbidities and gastroesophageal reflux disease were recruited in a gastroenterology clinic. The followings were conducted at 4 weeks after index oesophagogastroduodenoscopy: self-administrated questionnaires on socio-demographics, dyspeptic symptom severity (4-point Likert scale), GHQ-12, and 36-item short-form health survey (SF-36). Psychiatric disorders were diagnosed with Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) by a trained psychiatrist, which served as reference standard. RESULTS: 55 patients underwent psychiatrist-conducted interview and questionnaire assessment. 27 (49.1%) had current psychiatric disorders as determined by SCID (anxiety disorders: 38.2%, depressive disorders: 16.4%). Receiver operating characteristic curve analysis of GHQ-12 revealed an area under curve of 0.825 (95%CI: 0.698-0.914). Cut-off of GHQ-12 at > or =3 gave a sensitivity of 63.0% (95%CI = 42.4-80.6%) and specificity of 92.9% (95%CI = 76.5%-98.9%). Subjects with co-existing psychiatric disorders scored significantly lower in multiple domains of SF-36 (mental component summary, general health, vitality and mental health). By multivariate linear regression analysis, current psychiatric morbidities (Beta = -0.396, p = 0.002) and family history of psychiatric illness (Beta = -0.299, p = 0.015) were independent risk factors for poorer mental component summary in SF-36, while dyspepsia severity was the only independent risk factor for poorer physical component summary (Beta = -0.332, p = 0.027). CONCLUSIONS: Concomitant psychiatric disorders adversely affect HRQoL in FD patients. The use of GHQ-12 as a reliable screening tool for psychiatric disorders allows early intervention and may improve clinical outcomes of these patients.
