Localized periorbital edema as a clinical manifestation of sulfite sensitivity.
10.3346/jkms.1996.11.4.356
- Author:
Hae Sim PARK
1
;
Dongho NAHM
Author Information
1. Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
- Publication Type:Case Report
- Keywords:
Perioibital edema;
Sulfite-sensitivity
- MeSH:
Allergens/*therapeutic use;
Case Report;
Edema/*etiology;
Female;
Human;
Middle Age;
Orbital Diseases/*etiology;
Skin Diseases/drug therapy;
Sulfites/*therapeutic use
- From:Journal of Korean Medical Science
1996;11(4):356-357
- CountryRepublic of Korea
- Language:English
-
Abstract:
Sulfite is commonly used in pharmaceuticals as a preservative. We report a unique clinical presentation of localized periorbital edema on the left eye after administration of sulfite-containing dexamethasone. The patient's sulfite sensitivity was confirmed by sulfite oral provocation test: periorbital edema on the same site developed after ingestion of 200 mg sodium bisulfite. She was non-atopic and did not complain of any respiratory symptoms. Allergy skin prick test with 100 mg/ml sodium bisulfite showed a negative result. She also has aspirin-sensitive urticaria which was confirmed by oral provocation test. In conclusion, sulfite can induce a localized periorbital edema, an uncommon manifestation in sensitive patients. Further investigations are needed to clarify the pathogenetic mechanisms.
