Effects of Propofol on Arginine Vasopressin-induced Contraction in Isolated Human Gastroepiploic Artery.
10.4097/kjae.2008.54.6.662
- Author:
Sung Jin LEE
1
;
Seong Wan BAIK
;
Hyeok Rae CHO
;
Won Sung KIM
;
Seung Hoon BAEK
Author Information
1. Department of Anesthesiology and Pain Medicine, Pusan National University College of Medicine, Busan, Korea. swbaik@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
coronary artery bypass grafting;
propofol;
vasopressin
- MeSH:
Arginine;
Arginine Vasopressin;
Arteries;
Calcium;
Contracts;
Coronary Artery Bypass;
Diltiazem;
Endothelium;
Gastrectomy;
Gastroepiploic Artery;
Glyburide;
Humans;
Nicorandil;
Potassium Channels;
Propofol;
Shock;
Spasm;
Transplants;
Vasopressins
- From:Korean Journal of Anesthesiology
2008;54(6):662-668
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Arginine vasopressin has been used by prophylactic treatment of vasodilatory shock during coronary artery bypass graft (CABG). Vasopressin may be a cause of spasm in graft artery during CABG. We evaluated the effect of propofol on vasopressin-induced contraction in human gastroepiploic artery (GEA). METHODS: Human GEA were obtained from 35 patients (43-74 yr), undergoing subtotal gastrectomy. Vasopressin-induced a concentration contractions (10(-9) to 10(-6) M) were measured after exposed to without propofol, propofol 10(-5), 10(-4), 10(-3) M. After endothelium denuding vasopressin-induced a concentration contractions were measured with or without propofol 10(-3) M in calcium free solution. In the denuded vascular rings, with or without pretreatment of glibenclamide (10(-5) M), nicorandil (10(-5) M), or diltiazem (10(-5) M) were exposed to with or without propofol 10(-3) M, and vasopressin-induced concentration contractions were measured. RESULTS: Vasopressin-induced concentration contraction on human GEA was independent of functional endothelium. Propofol (10(-4), 10(-3) M) attenuated the vasopressin-induced contraction in the human GEA. Diltiazem attenuated the vasopressin-induced contraction in the human GEA. ATP-sensitive potassium channel does not affect the inhibition effect of propofol on vasopressin-induced contraction CONCLUSIONS: Usual anesthetic dose of propofol does not inhibit vasopressin-induced contraction on human GEA. High dose (>10(-4) M) propofol attenuated vasopresssi-induced contraction on GEA.
