Increased Expression of Cyclooxygenase-2 is Associated with the Progression to Cirrhosis.
10.3904/kjim.2010.25.4.364
- Author:
Soung Won JEONG
1
;
Jae Young JANG
;
Sae Hwan LEE
;
Sang Gyun KIM
;
Young Koog CHEON
;
Young Seok KIM
;
Young Deok CHO
;
Hong Soo KIM
;
Joon Seong LEE
;
So Young JIN
;
Chan Sup SHIM
;
Boo Sung KIM
Author Information
1. Institute for Digestive Research and Digestive Disease Center, Soonchunhyang University College of Medicine, Seoul, Korea. jyjang@hosp.sch.ac.kr
- Publication Type:Original Article
- Keywords:
Cyclooxygenase 2;
Immunohistochemistry;
Hepatitis, chronic;
Liver cirrhosis
- MeSH:
Adult;
Aged;
Cyclooxygenase 2/analysis/*physiology;
Cyclooxygenase 2 Inhibitors/therapeutic use;
Disease Progression;
Female;
Hepatitis, Chronic/enzymology;
Humans;
Immunohistochemistry;
Liver Cirrhosis/drug therapy/*enzymology;
Male;
Middle Aged
- From:The Korean Journal of Internal Medicine
2010;25(4):364-371
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: To investigate the degree of cyclooxygenase-2 (COX-2) protein expression in chronic hepatitis and cirrhosis. METHODS: COX-2 protein expression was evaluated in 43 cases of chronic hepatitis and 24 cases of cirrhosis using immunohistochemical techniques. The COX-2 immunohistochemical staining score was assessed using the scoring systems of Pazirandeh et al and Qiu et al. and each scoring system was based on a sum of the parameters of staining intensity and distribution. RESULTS: The mean COX-2 expression scores in chronic hepatitis and cirrhosis were 2.5 +/- 1.3 vs. 3.3 +/- 1.1 (p = 0.008), and 3.2 +/- 2.0 vs. 4.5 +/- 1.7 (p = 0.006), respectively, based on the Pazirandeh et al. and Qiu et al. scoring systems. The percentage samples of high COX-2 expression score (4 to 5) in chronic hepatitis and cirrhosis were 16.3% vs. 45.8% (p = 0.022), and 23.3% vs. 50% (p = 0.021), respectively, based on the two scoring systems. The mean COX-2 expression scores based on the severity of hepatic fibrosis scored using Ishak's modified staging system (fibrosis score 0 to 3 vs. 4 to 6) were 2.4 +/- 1.3 vs. 3.2 +/- 1.1 (p = 0.009), and 3.1 +/- 2.0 vs. 4.3 +/- 1.8 (p = 0.009), respectively, based on the two scoring systems. CONCLUSIONS: COX-2 expression was significantly higher in liver cirrhosis group than in chronic hepatitis. COX-2 expression scores according to Ishak's staging was significantly higher in the advanced fibrosis group. COX-2 may play a role in the progression of hepatic fibrosis.
