Association of the Superoxide Dismutase (V16A) and Catalase (C262T) Genetic Polymorphisms with the Clinical Outcome of Patients with Acute Paraquat Intoxication.
10.3904/kjim.2010.25.4.422
- Author:
Joong Rock HONG
1
;
Su Jin SEOK
;
Du Shin JEONG
;
Sang Gon LEE
;
Hyo Wook GIL
;
Jong Oh YANG
;
Eun Young LEE
;
Sae Yong HONG
Author Information
1. Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea. syhong@sch.ac.kr
- Publication Type:Original Article
- Keywords:
Polymorphism, genetic;
Superoxide dismutase;
Catalase;
Paraquat;
Glutathione peroxidase GPX1
- MeSH:
Acute Disease;
Adult;
Aged;
Catalase/*genetics;
Female;
Genotype;
Glutathione Peroxidase/genetics;
Humans;
Male;
Middle Aged;
Paraquat/*poisoning;
Poisoning/mortality;
*Polymorphism, Genetic;
Superoxide Dismutase/*genetics
- From:The Korean Journal of Internal Medicine
2010;25(4):422-428
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Many patients with acute paraquat (PQ) intoxication die even at low PQ concentrations, whereas others with similar concentrations recover. Therefore, it is possible that individual differences in antioxidant capacity are responsible for the variable clinical outcome in patients with acute PQ intoxication. METHODS: We investigated whether there was a relationship between the genetic polymorphisms of SOD (V16A), catalase (C262T), and GPX1 (C593T) in 62 patients with acute PQ intoxication and the clinical outcomes of these patients. RESULTS: The frequency of the Mn-SOD V/V, V/A, and A/A genotypes were 56.3, 43.5, and 0% in survivors and 86.9, 13.1, and 0% in non-survivors (p > 0.05). The GPX1 C/C, C/T, and T/T genotypes were present in 100, 0, and 0% of all subjects. The catalase C/C, C/T, and T/T genotypes were present in 100, 0, and 0% of survivors, and in 82.6, 17.4, and 0% of non-survivors. Neither erythrocyte SOD activity nor catalase activity were significantly different between survivors and non-survivors. CONCLUSIONS: No association was found between clinical outcome of acute PQ intoxication and the genetic polymorphism of GPX1 (C593T) or the genetic polymorphisms or enzyme activity of superoxide dismutase (V16A) or catalase (C262T).
