Thalidomide Induced Nonspecific Interstitial Pneumonia in Patient with Relapsed Multiple Myeloma.
10.3904/kjim.2010.25.4.447
- Author:
Myung Hee KANG
1
;
Ji Hyun JU
;
Hoon Gu KIM
;
Jung Hun KANG
;
Kyung Nyeo JEON
;
Ho Cheol KIM
;
Gyeong Won LEE
Author Information
1. Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. brightree@lycos.co.kr
- Publication Type:Case Report
- Keywords:
Lung diseases, interstitial;
Thalidomide;
Multiple myeloma
- MeSH:
Female;
Humans;
Lung Diseases, Interstitial/*chemically induced;
Middle Aged;
Multiple Myeloma/*drug therapy;
Thalidomide/*adverse effects/therapeutic use
- From:The Korean Journal of Internal Medicine
2010;25(4):447-449
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 63-year-old female diagnosed with relapsed multiple myeloma visited our hospital complaining of a persistent cough. Since July 2006, she had been taking 100 mg thalidomide daily and gradually developed shortness of breath and a persistent dry cough. A chest X-ray and computed tomography showed ground glass opacities in both lungs. An open lung biopsy of the right middle lobe under general anesthesia revealed chronic peribronchial inflammation, mild interstitial fibrosis, and intra-alveolar macrophage infiltration, with some hemosiderin features, compatible with non-specific interstitial pneumonia (NSIP). After discontinuing the thalidomide, the patient's symptoms did not deteriorate, although the radiographs did not improve. The patient is alive and well with regular outpatient follow-up without progression of the NSIP.
