Updates on desensitization for hypersensitivity reactions related to chemotherapy.
10.4168/aard.2013.1.4.295
- Author:
Suh Young LEE
1
;
Min Suk YANG
;
Jae Woo JUNG
;
Mi Jung OH
;
Chang Han PARK
;
Seong Wook SOHN
;
Hye Ryun KANG
;
Young Joo CHO
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. helenmed@snu.ac.kr
- Publication Type:Review
- Keywords:
Immunologic desensitization;
Antineoplastic agents;
Drug hypersensitivity
- MeSH:
Antineoplastic Agents;
Desensitization, Immunologic;
Drug Hypersensitivity;
Drug Therapy*;
Humans;
Hypersensitivity*
- From:Allergy, Asthma & Respiratory Disease
2013;1(4):295-302
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
As the use of chemotherapeutic agents increased rapidly in recent years, more patients are under the potential risk of chemotherapy related adverse reactions. Multiple regular exposures to the same drug by chemotherapy protocol may increase the risk of sensitization to a chemotherapeutic agent, which can result in hypersensitivity reactions. Once severe hypersensitivity reactions occur, causative drugs should be avoided. However, a substitute with equal efficacy is not always available. When there is no effective alternative, desensitization is a safe tool for maintenance of chemotherapeutic agents causing hypersensitivity reaction. In this review, we introduce the latest knowledge about desensitization protocol for chemotherapeutic agents which are frequently used recently.
