Comparison of bronchial responsiveness assessing dose-response slope between cough-variant asthma and classic asthma in young children.
10.4168/aard.2013.1.4.309
- Author:
Jung Won YOON
1
;
Hye Young HUR
;
Hye Mi JEE
;
Ji Hyeon BAEK
;
Hyeong Yoon KIM
;
Youn Ho SHIN
;
Man Yong HAN
Author Information
1. Department of Pediatrics, Myongji Hospital, Goyang, Korea.
- Publication Type:Original Article
- Keywords:
Oscillometry;
Cough;
Asthma;
Dose response;
Bronchial hyperreactivity
- MeSH:
Airway Resistance;
Asthma*;
Bronchial Hyperreactivity;
Child*;
Cough;
Diagnosis, Differential;
Humans;
Lung;
Methacholine Chloride;
Oscillometry;
Respiratory Function Tests
- From:Allergy, Asthma & Respiratory Disease
2013;1(4):309-313
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Little data is currently available on the use of the impulse oscillometry system (IOS) parameter in analyzing the lung function of young children with cough-variant asthma (CVA) and classic asthma. The aims of this study were to evaluate the bronchial responsiveness between patients with CVA and those with classic asthma using dose-response slope and various cutoff values. METHODS: A methacholine challenge test and a pulmonary function test were performed in 43 children with classic asthma and 26 children with CVA using IOS, and the respiratory resistance (Rrs) and reactance (Xrs) were obtained. The bronchial responsiveness were assessed by provocative concentration causing an 80% fall from baseline in reactance at 5 Hz (PC80_Xrs5) and a 40% increase in resistance at 5 Hz (PC40_Rrs5) and calculating from the degree of dose-response slope (DRS) for airway resistance and reactance. RESULTS: There was no significant difference in base lung function between the two groups. However, the mean DRS_Xrs5 and the number who showed more than an 80% fall in reactance were significantly higher in classic asthma group than those in CVA group (P=0.040 and P=0.040, respectively). CONCLUSION: The use of DRS in oscillatory reactance at 5 Hz is useful for the differential diagnosis of classic asthma and CVA based on bronchial hyperresponsiveness.
