Dapsone-induced drug reaction with eosinophilia and systemic symptoms syndrome, misdiagnosed as lymphoma.
10.4168/aard.2013.1.4.400
- Author:
Bomi SHIN
1
;
So Young PARK
;
Sun Young YOON
;
Eun Hye SHIN
;
Young Joo YANG
;
Hyung Jin CHO
;
Il Young JANG
;
Dong Uk KANG
;
Tae Bum KIM
;
You Sook CHO
;
Hee Bom MOON
;
Hyouk Soo KWON
Author Information
1. Department of Allergy and Clinical Immunology, Asan Medical Center, Seoul, Korea. kwonhs21@naver.com
- Publication Type:Case Report
- Keywords:
DRESS syndrome;
Dapsone;
Pseudolymphoma;
Drug hypersensitivity
- MeSH:
Biopsy;
Dapsone;
Diagnosis, Differential;
Drug Hypersensitivity;
Drug Hypersensitivity Syndrome*;
Drug Therapy;
Drug-Related Side Effects and Adverse Reactions;
Eosinophilia;
Exanthema;
Fever;
Humans;
Leprosy;
Liver;
Lymph Nodes;
Lymphatic Diseases;
Lymphoma;
Lymphoma, T-Cell, Peripheral;
Prurigo;
Pseudolymphoma;
Skin
- From:Allergy, Asthma & Respiratory Disease
2013;1(4):400-404
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction with systemic manifestations. Dapsone is known to be useful for treatment of leprosy and various dermatologic conditions. We report a patient with prurigo pigmentosa who developed DRESS syndrome after dapsone treatment. She presented with lymphadenopathy, fever, eosinophilia, skin rash, and elevated liver enzymes. Initial lymph node and skin biopsy was suggestive of peripheral T-cell lymphoma. Initially, she was treated with chemotherapy. A week later after complete remission of skin symptoms, new skin lesions recurred. TCR-gene rearrangement was examined to show negative results and she was diagnosed as dapsone induced DRESS syndrome. This case emphasizes the importance of differential diagnosis of lymphoma and DRESS syndrome.
