The Effects of Intravenous Patient-Controlled Analgesia using Morphine or Nalbuphine to Postoperative Respiratory Depression.
10.4097/kjae.1996.31.3.391
- Author:
Sun Ok SONG
1
;
Gun Yong YOOK
;
Sun Kyo SONG
Author Information
1. Department of Anesthesiology, College of Medicine, Yeungnam University, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Analgesia patient-controlled (PCA);
intravenous PCA(IV-PCA);
Analgesics morphine;
nalbuphine;
Pain postoperative;
Complication respiratory depression
- MeSH:
Analgesia, Patient-Controlled*;
Analgesics, Opioid;
Anesthesia, General;
Blood Gas Analysis;
Humans;
Infusion Pumps;
Morphine*;
Nalbuphine*;
Pain, Postoperative;
Passive Cutaneous Anaphylaxis;
Respiratory Insufficiency*;
Respiratory Rate
- From:Korean Journal of Anesthesiology
1996;31(3):391-398
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The aim of this study was to evaluate the effects of respiratory depression of IV-PCA using morphine which has potent respiratory depression or nalbuphine which has less potent respiratory depression among opioids. METHODS: Forty patients were divided into two groups; Group M was used morphine, and Group N was used nalbuphine as a drug for IV-PCA. When patient emerges from general anesthesia, Group M was given initial bolus of 0.1 ml/kg of 0.1% morphine solution and connected Basal Bolus PCA infusor R containing morphine 50 mg per 40 ml in normal saline. Group N, similarly Group M, was given initial bolus of 0.1 ml/kg of 0.1% nalbuphine solution, and connected PCA infusor containing nalbuphine 50 mg per 40 ml in normal saline. To compare respiratory depression, arterial blood gas analyses were done preoperatively and at 1, 6 and 12 hour after IV-PCA. Simultaneously, analgesic and side effects were evaluated. RESULTS: There were no remarkable respiratory depression such as hypercarbia(PaCO2 > 50 mmHg), hypoxemia(PaO2 < 60 mmHg) and slow respiratory rate in both groups. Analgesic and side effects were similar in both groups. CONCLUSIONS: We conclude that IV-PCA using morphine or nalbuphine is relatively effective and safe method for the postoperative pain control. Ordinarily, IV-PCA dose not induce respiratory depression unless overdose in careless or mistaken mishaps are developed.
