A Case of Familial Clustering of Hepatitis C Virus.
- Author:
Hoon JEUNG
1
;
Hyeun Sub JANG
;
Yun Jin LEE
;
Kyun Woo LEE
;
Hye Young KIM
;
Jae Hong PARK
Author Information
1. Department of Pediatrics, Dae-Dong Hospital, Korea.
- Publication Type:Case Report
- Keywords:
Hepatitis C;
Familial clustering
- MeSH:
Anorexia;
Biopsy;
Child;
Cluster Analysis*;
Epidemiology;
Family Characteristics;
Female;
Fibrosis;
Hepacivirus*;
Hepatitis C*;
Hepatitis*;
Hepatitis, Chronic;
Humans;
Interferon-alpha;
Liver;
Mothers;
Nausea;
Nuclear Family;
RNA;
Vomiting
- From:Korean Journal of Pediatric Gastroenterology and Nutrition
2005;8(1):91-95
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The familial environment may also play an important role in the epidemiology of HCV infection through vertical and horizontal transmission by infected household members. However, it is still controversial whether familial clustering of HCV occurs. We experienced a case of familial clustering of hepatitis C virus. A 10-year old girl presented with nausea, vomiting and anorexia for a month was diagnosed as hepatitis C. Her mother, grandmother, a maternal aunt and her daughter had contracted with HCV. Her laboratory findings showed AST/ALT 63/122 IU/L, positive anti-HCV Ab and HCV RNA (3.54 x 10(5) copies/mL). Pathologic findings of the liver biopsy revealed chronic hepatitis with minimal lobular activity, mild porto-periportal activity and mild portal fibrosis. After treatment with interferon-alpha 2b for 6 months, the clinical symptoms and laboratory findings were normalized.
