XPD Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck in a Korean Sample.
- Author:
Yong Bae JI
1
;
Kyung TAE
;
Yoon Seo LEE
;
Seung Hwan LEE
;
Kyung Rae KIM
;
Chul Won PARK
;
Byung Lae PARK
;
Hyoung Doo SHIN
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Hanyang University College of Medicine, Seoul, Korea. kytae@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Polymorphism;
XPD;
Head and neck cancer;
Squamous cell carcinoma
- MeSH:
Carcinoma, Squamous Cell;
DNA Repair;
Drinking;
Genotype;
Haplotypes;
Head;
Head and Neck Neoplasms;
Humans;
Neck;
Odds Ratio;
Polymorphism, Single Nucleotide;
Smoke;
Smoking
- From:Clinical and Experimental Otorhinolaryngology
2010;3(1):42-47
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: XPD is a major player in nucleotide excision repair, which is one of the basic pathways of DNA repair. The objective of this study was to investigate the association of XPD single nucleotide polymorphisms (SNPs) and the risk of squamous cell carcinoma of the head and neck (SCCHN) in Koreans. METHODS: We performed XPD +23591G>A and +35931A>C genotyping in 290 SCCHN patients and 358 controls. RESULTS: The frequencies of the XPD +23591G>A (GG/GA/AA) genotypes were 89.0%/11.0%/0% in the patients and 90.3%/8.8%/0.9% in the controls, respectively. The odds ratio (OR) of the XPD +23591 GA genotype was 1.94 (0.92 to 4.08) in reference to the GG genotype. The frequencies of the XPD +35931A>C (AA/AC/CC) genotypes were 86.9%/12.0%/1.1% in the patients and 85.6%/13.8%/0.6% in the controls, respectively. The OR of the XPD +35931 AC and CC genotypes were 0.98 (0.51 to 1.88) and 2.68 (0.71 to 10.1), respectively, in reference to the AA genotype. On the subgroup analyses according to the smoking and drinking statuses, the SNPs and haplotypes of XPD showed no statistically significant association with the risk of SCCHN. CONCLUSION: The results of this study suggest that the XPD +23591G>A and +35931A>C SNPs are not associated with the risk of SCCHN in Koreans; however, a further study with a larger number of subjects is necessary to verify this conclusion.
