Anti-obesity effects of Rapha diet(R) preparation in mice fed a high-fat diet.
10.5625/lar.2012.28.4.265
- Author:
Jihyun KIM
1
;
Jangbeen KYUNG
;
Dajeong KIM
;
Ehn Kyoung CHOI
;
Paul BANG
;
Dongsun PARK
;
Yun Bae KIM
Author Information
1. College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea. solar93@cbu.ac.kr
- Publication Type:Original Article
- Keywords:
Obesity;
high-fat diet;
Rapha diet(R) preparation;
lipid accumulation;
adipocyte size
- MeSH:
Abdominal Fat;
Adipocytes;
Animals;
Body Weight;
Bombyx;
Cacao;
Cholesterol;
Diet, High-Fat;
European Continental Ancestry Group;
Garcinia cambogia;
Humans;
Male;
Mangifera;
Mice;
Obesity;
Pupa;
Tea;
Triglycerides;
Weights and Measures
- From:Laboratory Animal Research
2012;28(4):265-271
- CountryRepublic of Korea
- Language:English
-
Abstract:
The anti-obesity activities of Rapha diet(R) preparation containing silkworm pupa peptide, Garcinia cambogia, white bean extract, mango extract, raspberry extract, cocoa extract, and green tea extract were investigated in mice with dietary obesity. Male C57BL/6 mice were fed a high-fat diet (HFD) containing 3% Rapha diet(R) preparation for 8 weeks, and blood and tissue parameters of obesity were analyzed. The HFD markedly enhanced body weight gain by increasing the weights of epididymal, perirenal, and mesenteric adipose tissues. The increased body weight gain induced by HFD was significantly reduced by feeding Rapha diet(R) preparation, in which decreases in the weight of abdominal adipose tissue and the size of abdominal adipocytes were confirmed by microscopic examination. Long-term feeding of HFD increased blood triglycerides and cholesterol levels, leading to hepatic lipid accumulation. However, Rapha diet(R) preparation not only reversed the blood lipid levels, but also attenuated hepatic steatosis. The results indicate that Rapha diet(R) preparation could improve HFD-induced obesity by reducing both lipid accumulation and the size of adipocytes.
