The Clinical Characteristics and Predictive Factors of Stage IV Breast Cancer at the Initial Presentation: A Review of a Single Institute's Data.
10.4048/jbc.2007.10.2.101
- Author:
Eun Young KIM
1
;
Seeyoun LEE
;
Tae Seok BAE
;
Seok Won KIM
;
Youngmee KWON
;
Eun A KIM
;
Jungsil RO
;
Eun Sook LEE
Author Information
1. Center for Breast Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea. eunsook@ncc.re.kr
- Publication Type:Original Article
- Keywords:
Breast cancer;
Clinical characteristics;
Metastasis;
Predictive factor
- MeSH:
Alkaline Phosphatase;
Aspartic Acid;
Breast Neoplasms*;
Breast*;
Humans;
Korea;
Liver;
Lung;
Lymph Nodes;
Multivariate Analysis;
Neoplasm Metastasis;
Prospective Studies;
Transferases
- From:Journal of Breast Cancer
2007;10(2):101-106
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of this study is to evaluate stage IV breast cancer at the initial presentation by the review of a single institute' data. We also tried to figure out the factors to predict stage IV breast cancer. METHODS: We reviewed the prospectively collected database of 1,424 consecutive patients with primary breast cancer at the National Cancer Center in Korea from October 2000 to January 2005. RESULTS: The proportion of stage IV breast cancer was 2.7% (38/1,424). The median tumor size of the stage IV patients was 4.1 cm. The most common metastatic site was bone (47.4%) followed by lung (44.7%) and liver (36.8%). Metastases were found in 0.9% (6/672) of the T1 tumors, 2.4% (13/535) of the T2 tumors, 8.3% (4/48) of the T3 tumors, and 27.1% (13/48) of the T4 tumors (p<0.001). On multivariate analysis, the statistically significant predictors of distant metastasis were tumor size (> or =2 cm) (p=0.026), positive lymph node status (p<0.001), alkaline phosphatase (>104 IU/L) (p=0.013), aspartate transferase (>40 IU/L) (p=0.003) and CA15-3 (>32 U/mL) (p=0.025). CONCLUSION: Our study showed that the factors to predict distant metastasis of breast cancer were large size of tumor, positive lymph node status, elevated alkaline phosphatase, aspartate transferase and CA15-3. Therefore breast cancer patients with those clinical characteristics should be carefully evaluated to detect distant metastasis.
