NF-kappaB Activation in T Helper 17 Cell Differentiation.
- Author:
Sang Heon PARK
1
;
Gabi CHO
;
Sung Gyoo PARK
Author Information
- Publication Type:Review
- Keywords: NF-kappaB; Th17; T cell receptor; Autoimmune
- MeSH: Cell Differentiation*; Cell Survival; Gene Expression; Ligation; NF-kappa B*; Receptors, Antigen, T-Cell; Th17 Cells
- From:Immune Network 2014;14(1):14-20
- CountryRepublic of Korea
- Language:English
- Abstract: CD28/T cell receptor ligation activates the NF-kappaB signaling cascade during CD4 T cell activation. NF-kappaB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-kappaB activation is also involved in T helper (Th) cell differentiation including Th17 cell differentiation. In this review, we discuss the current literature on NF-kappaB activation pathway and its effect on Th17 cell differentiation.
