Modulation of Melanin Synthesis by Amaranthus spp. L Seed Extract in Melan-a Cells.
10.20307/nps.2016.22.3.168
- Author:
Jae Ok SEO
1
;
Moon Ho DO
;
Jae Hak LEE
;
Taek Hwan LEE
;
Hussain Mustatab WAHEDI
;
Yong Un PARK
;
Sun Yeou KIM
Author Information
1. College of Pharmacy, Gachon University, Yeonsu-gu, Incheon, Republic of Korea. sunnykim@gachon.ac.kr
- Publication Type:Original Article
- Keywords:
Amaranth;
Myo-inositol;
Melan-a cells;
Melanogenesis
- MeSH:
Amaranthus*;
Chromatography, High Pressure Liquid;
MART-1 Antigen*;
Melanins*;
Melanocytes;
Monophenol Monooxygenase;
Squalene;
Water
- From:Natural Product Sciences
2016;22(3):168-174
- CountryRepublic of Korea
- Language:English
-
Abstract:
Anti-melanogenic effects of amaranth (AT), one of the key source of squalene, were investigated in melanocytes. Amaranth seed powder was extracted with water and melan-a cells were treated with various concentrations of AT. By using HPLC, content of myo-inositol, one of potential active components, was measured in the crude extract of AT.AT reduced the melanin content in melan-a melanocytes and down-regulated melanogenic enzyme activity such as tyrosinase, TRP-1 and TRP-2. By regulating melanogenic enzyme activity, AT may be a potential natural source for whitening agent. Myo-inositol was detected in AT by HPLC and may be one of the active compounds from AT involved in the regulation of anti-melanogenesis. In this study, we demonstrated that AT has anti-melanogenesis properties. This new function of amaranth may be useful in the development of new skin-whitening products and its value as food.
