Adjuvant Treatment with Chemotherapeutic Agents and Polyadenylic-Polyuridylic Acid in Operable Stomach Cancers: I. Enhancement of Natural Killer Cell Activity.
- Author:
Jung Koo YOUN
1
;
Byung Soo KIM
;
Jin Sik MIN
;
Heung Jai CHOI
;
Yoo Bock LEE
;
Dong Woo LEE
;
Eun Hee KOH
;
Kyung Won KIM
;
Kyi Beom LEE
;
Michael MICHELSON
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Stomach cancer; NK activity; chemotherapy; poly(A).poly(U)
- MeSH: Adult; Aged; Combined Modality Therapy; Doxorubicin/therapeutic use; Female; Fluorouracil/therapeutic use; Human; Killer Cells, Natural/drug effects*; Male; Middle Age; Poly A-U/pharmacology; Poly A-U/therapeutic use*; Stimulation, Chemical; Stomach Neoplasms/drug therapy*; Stomach Neoplasms/surgery
- From:Yonsei Medical Journal 1985;26(1):1-7
- CountryRepublic of Korea
- Language:English
- Abstract: Natural Killer (NK) cell activity of 47 operable stomach cancer patients was sequentially studied before and after chemotherapy in association with polyadenylic. polyuridylic acid [poly(A).poly(U)]. NK activity was determined by an in vitro 4 h chromium release assay using nonadherent mononuclear cells isolated from peripheral bloods as effectors and human myeloblastic cells (K562) as targets. The following results were obtained: 1) The mean NK activity of the 47 patients tested before chemotherapy was significantly lower than that of 14 healthy controls. 2) The patents who received chemotherapy consisting of 5 FU (12 mg/kg) and adriamycin (40 mg/M2) showed an increase in NK activity 5 days after injection as compared to that of the same patients tested before chemotherapy. 3) In these patients, an additional administration of poly(A) poly(U) (100mg) resulted in a further significant increase of NK activity 2 days later, whereas the control patients who received placebo showed no change of NK activity.