Effects of the Single Administration of the Anticholonergics, Trospium Chloride, on the Patients with Nocturia.
- Author:
Jin WEN
1
;
Dong Il KANG
;
Sung Hyup CHOI
;
Kweon Sik MIN
Author Information
1. YanBian Maternal and Child Hygiene Hospital, China.
- Publication Type:Original Article
- Keywords:
Nocturia;
Treatment;
Anticholinergics
- MeSH:
Cholinergic Antagonists;
Female;
Humans;
Hypnotics and Sedatives;
Lower Urinary Tract Symptoms;
Male;
Mouth;
Nocturia*;
Polyuria;
Urinary Bladder;
Urinary Bladder Neck Obstruction;
Urinary Bladder, Overactive;
Urinary Incontinence, Urge
- From:Journal of the Korean Continence Society
2005;9(2):75-81
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to evaluate the effects of the single administration of the anticholonergics, trospium chloride, in the nocturic patients without bladder outlet obstruction for mid-term. MATERIALS AND METHODS: We included the 22 male and 102 female patients with nocturia over 3 times and without bladder outlet obstruction. Exclusion criteria was under 15 ml/sec in maximal flow rate, over 30 ml in post-void residual urine, nocturnal polyuria and medication affecting lower urinary tract symptoms including alpha-blockers, sedatives, muscle relaxants. Based on voiding diary for 3 days, frequency of the nocturia, daytime frequency and frequency of the urgency and urge incontinence were measured at pretreatment, post-treatment 1st month, 3rd month and 6th month. Additionally maximal flow rate and post-void residual urine were also recorded at the same periods. Anticholinergics was administered in flexible dose. RESULTS: In frequency of nocturia, single administration of the anticholonergics improved significantly at post-treatment 1st, 3rd and 6th month compared to pre-treatment level. The more severe the frequency of the nocturia was, the more it was improved by medication but there is no significant difference. Daytime frequency is significantly improved 3 month and 6 month after medication. In urgency and urge incontinence, the significant improvement was also observed at post-treatment 3rd month and 6th month. The significant differences between pre-treatment and post-treatment were not demonstrated in maximal flow rate and post-void residual urine. Dry mouth was the most common side effect but mild and tolerable. CONCLUSION: The single administration of the trospium chloride demonstrated a clinically significant improvement in nocturia as well as symptoms of the overactive bladder and did not affect negatively on bladder contractility.
