Effect of Low Power Laser Irradiation on Gentamicin-Damaged Vestibular System in Guinea Pigs.
- Author:
Chung Ku RHEE
1
;
Myoung Chan KIM
;
Eun Seok LIM
;
Young Saeng KIM
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Dankook University, Cheonan, Korea. rheeck@dku.edu
- Publication Type:Original Article
- Keywords:
Low level laser;
Vestibular system;
Gentamicin;
Ototoxicity;
Rotation test
- MeSH:
Acceleration;
Animals;
Axis, Cervical Vertebra;
Gentamicins;
Guinea Pigs*;
Guinea*;
Low-Level Light Therapy*;
Otolithic Membrane
- From:Journal of the Korean Balance Society
2005;4(2):225-229
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: The purpose of this study was to investigate the characteristics of gentamicin-induced vestibulotoxicity of otolith organs and preventive effect of low power laser to vestibulotoxicity by assessing the result of earth vertical and the off vertical axis rotation tests. MATERIALS AND METHODS: Twenty guinea pigs were grouped into two groups, laser and no laser group. Vestibulotoxicity was induced by intratympanic injection of gentamicin. Prevention of the vestibulotoxicity was studied by irradiation of low power laser. Off vertical axis rotation tilted 30 degree relative to the earth vertical axis was applied to evaluate the otolithic function. Results and CONCLUSION: Gentamicin induced vestibulotoxicity was confirmed by gain decreasing in slow harmonic acceleration test and modulation decreasing in the off vertical axis rotation test. Prevention effect of low power laser to gentamicin induced vestibulotoxicity was confirmed by modulation maintaining in the off vertical axis rotation test and gain maintaining in the earth vertical axis rotation.
