Effectiveness of Premedication with Pronase for Visualization of the Mucosa during Endoscopy: A Randomized, Controlled Trial.
- Author:
Gyu Jin LEE
1
;
Seun Ja PARK
;
Sun Jung KIM
;
Hyung Hun KIM
;
Moo In PARK
;
Won MOON
Author Information
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords: Pronase; Premedication
- MeSH: Dimethylpolysiloxanes; Endoscopy; Flushing; Humans; Mucous Membrane; Mucus; Outpatients; Premedication; Pronase; Sodium Bicarbonate; Unithiol
- From:Clinical Endoscopy 2012;45(2):161-164
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Gastric mucus should be removed before endoscopic examination to increase visibility. In this study, the effectiveness of premedication with pronase for improving visibility during endoscopy was investigated. METHODS: From April 2010 to February 2011, 400 outpatients were randomly assigned to receive endoscopy with one of four premedications as follows: dimethylpolysiloxane (DMPS), pronase and sodium bicarbonate with 10 minutes premedication time (group A, n=100), DMPS and sodium bicarbonate with 10 minutes premedication time (group B, n=100), DMPS, pronase and sodium bicarbonate with 20 minutes premedication time (group C, n=100), and DMPS and sodium bicarbonate with 20 minute premedication time (group D, n=100). One endoscopist, who was unaware of the premedication types, calculated the visibility scores (range, 1 to 3) of the antrum, lower gastric body, upper gastric body and fundus. The sum of the scores from the four locations was defined as the total visibility score. RESULTS: Group C showed significantly lower scores than other groups (p=0.002). Group C also had the lowest frequency of flushing, which was significantly lower than that of group D. Groups C and D had significantly shorter durations of examination than groups A and B. CONCLUSIONS: Using pronase 20 minutes before endoscopy significantly improved endoscopic visualization and decreased the frequency of water flushing.
