Impact of Drug-Eluting Stents on Clinical Outcomes in Patients With Diffuse Coronary Lesions.
10.4070/kcj.2008.38.11.612
- Author:
Hyeon Gook LEE
1
;
Kook Jin CHUN
;
Kyoung Im CHO
;
Dong Won LEE
;
Jun Hyuk OH
;
Byung Jae AHN
;
Seong Ho KIM
;
Joon Sang LEE
;
Moo Young KIM
;
Woo Hyung BAE
;
Woo Seog KO
;
Joon Hoon JEONG
;
Tae Ik KIM
;
Han Cheol LEE
;
Jun KIM
;
June Hong KIM
;
Taek Jong HONG
;
Yung Woo SHIN
Author Information
1. Division of Cardiology, Department of Internal Medicine, Maryknoll Medical Center, Busan, Korea.
- Publication Type:Original Article
- Keywords:
Coronary stenosis;
Drug-eluting stents;
Coronary restenosis
- MeSH:
Constriction, Pathologic;
Coronary Angiography;
Coronary Restenosis;
Coronary Stenosis;
Drug-Eluting Stents;
Follow-Up Studies;
Humans;
Stents
- From:Korean Circulation Journal
2008;38(11):612-617
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: In the era of stents, lesion length remains an important predictor of restenosis. Drug-eluting stents (DESs) have significantly reduced in-stent restenosis (ISR), but results in long lesions are still lacking. Therefore, we investigated the impact of DESs on clinical outcomes in patients with diffuse coronary lesions. SUBJECTS AND METHODS: Between January 2004 and January 2005, 80 patients (94 lesions) with lesions >20 mm in length were treated with one or more DESs and underwent follow-up coronary angiography. The patients were divided into three groups: Group 1 was composed of those with lesions 21 to 35 mm in length, Group 2 was composed of those with lesions 36 to 50 mm in length, and Group 3 was composed of those with lesions > or =51 mm in length. RESULTS: The mean clinical follow-up duration was 9 months. On the 6-month follow-up angiogram, 6.4% of the lesions had binary ISR (5.0% in group 1, 8.7% in group 2, and 9.1% in group 3). The percent diameter stenosis was 6.0+/-18.15% in Group 1, 12.61+/-21.99% in Group 2, and 19.81+/-31.26% in Group 3(p< 0.05). Late lumen loss was 0.17+/-0.50 mm in Group 1, 0.39+/-0.66 mm in Group 2, and 0.59+/-0.93 mm in Group 3 (p<0.05). Lesion length was associated with an increase in percent diameter stenosis and late lumen loss (of 6.9% and 0.21 mm per 15 mm). CONCLUSION: DES implantation is considered safe and effective in the treatment of diffuse lesions. However, lesion length may be associated with an increase in percent diameter stenosis and late lumen loss at 6-month follow-up.
